【Adverse reactions】 1. Nausea, vomiting, diarrhea and abdominal discomfort are more common. 2. Allergic reactions such as rash and drug fever. It is rare to have anaphylactic shock. 3. Dizziness, diplopia, tinnitus, convulsions and other nervous system reactions. 4. Occasionally, kidney damage occurs during the application of this product. 5. Occasionally, patients showed elevated serum aminotransferase and positive Coombs test. Hemolytic anemia is rare, and neutropenia and pseudomembranous colitis have also been reported. 6. The interference of trimethoprim on folate metabolism can cause adverse reactions in the blood system, which can lead to leukopenia, thrombocytopenia or methemoglobinemia. Generally, the white blood cells and thrombocytopenia are mild, and the drug can be recovered in time. The folic acid preparation can also be added.